Selamectin (brand names: Revolution®, Paradyne®, Stronghold®, Chanhold®) is an avermectin antiparasitic used topically to treat parasites in dogs and cats. When used in dogs, parasites treated by selamectin include fleas, heartworms, ear mites, scabies, and certain ticks.

How effective is selamectin?

Selamectin provided 60.4% and 91.4% efficacy with 24 and 48 hours of treatment, respectively. The efficacy 48 hours after infestations on Days 7, 14 & 21 were equivalent for all three products (Table 1). Following the Day 28 flea infestation selamectin was 93% and 95.7% effective at 24 and 48 hours, respectively.

What are side effects with selamectin?

Side effects are rare. A small percentage of cats may develop hair loss at the administration site. Other rare side effects include loss of appetite, vomiting, diarrhea, muscle tremors, itchiness, redness, lethargy, salivation, and increased breathing rate.

What does selamectin do to fleas?

Selamectin works by entering your pets bloodstream through the skin. There, it can kill internal parasites such as the heartworm by paralyzing their central nervous system. Selamectin also redistributes itself back to the skin from the bloodstream to treat external parasites such as ticks, fleas, and mites.

Where do you apply selamectin?


Quote from video: So you want to part the fur between the shoulder blades.

How long does it take for selamectin to start working?

This medication should take effect within 4 to 8 hours, and will reach full effectiveness within the first week. Gradual improvements in clinical signs should occur during this time. Avoid contact with human skin; if it occurs, wash the skin immediately and thoroughly.

Is selamectin the same as ivermectin?

Selamectin is a semisynthetic avermectin. Avermectins (ivermectinlike drugs) and milbemycins (milbemycin, doramectin, and moxidectin) are macrocyclic lactones. Avermectins and macrocyclic lactones share similarities, including mechanism of action.

Is selamectin a pesticide?

Lets look at Selamectin, the active ingredient in Revolution. This pesticide is applied on your dog’s skin, and is then absorbed into his body through the skin and hair follicles.

Is selamectin safe?

Selamectin has a wide margin of safety in both dogs and cats when used according to the label directions, although, there have been rare reports of neurologic dysfunction including seizures.